- Title
- Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
- Creator
- Zhang, Qisi; Kounde, Cyrille S.; De Vita, Elena; Kozakov, Dima; McCluskey, Adam; Harling, John D.; Fuchter, Matthew J.; Tate, Edward W.; Mondal, Milon; Greenfield, Jake L.; Baker, Jennifer R.; Kotelnikov, Sergei; Ignatov, Mikhail; Tinworth, Christopher P.; Zhang, Leran; Conole, Daniel
- Relation
- Chemical Communications Vol. 58, Issue 78, p. 10933-10936
- Publisher Link
- http://dx.doi.org/10.1039/d2cc03092f
- Publisher
- Royal Society of Chemistry
- Resource Type
- journal article
- Date
- 2022
- Description
- Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
- Subject
- proteolysis targeting chimeras (PROTACs); protein expression; protein degradation; controlled degradation
- Identifier
- http://hdl.handle.net/1959.13/1482782
- Identifier
- uon:51022
- Identifier
- ISSN:1359-7345
- Language
- eng
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